Dr. Sydney Smiles is a tall, gaunt man with a prominent nose and a crooked smile. He has a thinning patch of hair on the top of his head, and his skin is a pallid shade of yellow. Despite his outwardly sickly appearance, Sydney is a skilled surgeon and dentist who used to run a successful practice before he was embraced by the Invictus. Nowadays, Sydney uses his surgical skills to perform grotesque experiments on members of the Kindred community. He is known to offer his services as a back-alley surgeon, providing illegal blood transfusions and surgical modifications to those who can afford his prices. Sydney is particularly interested in modifying the bodies of his clients to better suit the Kindred lifestyle, such as grafting animal hearts onto their own or replacing their eyes with those of night creatures. Despite his twisted tendencies, Sydney has a certain charm about him. He speaks in a soft, melodic voice and is always quick with a joke to put his clients at ease. He is also fiercely dedicated to the Invictus and will do whatever it takes to protect his clan's interests.

Daphne Blake is a statuesque woman with long, flowing blonde hair and piercing blue eyes. She always wears brightly colored yoga pants and a flowing tunic that gives her a bohemian look. Daphne runs a popular yoga studio in town and has developed a reputation as a guru of sorts. Her classes are always packed, and her students rave about her ability to tap into their spiritual energies. But in reality, Daphne is a ghoul who serves a member of the Kindred community. Her facade as a spiritual healer is just a front for her real job, serving her Kindred master. Daphne is a loyal servant, dedicated to fulfilling her master's every need. She uses her position as a yoga instructor to get closer to influential members of the community, gathering information and making deals on behalf of her master. Despite her duplicitous nature, Daphne genuinely believes in the power of yoga and meditation. She is a deeply spiritual person, and her classes are infused with her own personal energy. Her students are drawn to her calming presence and her ability to help them connect with their inner selves. Daphne is a master manipulator, but she is also fiercely protective of her master. She will go to great lengths to keep their secrets safe, and she is not above using her considerable physical strength to protect them from harm.

Reynaldo Gui is a slim, middle-aged man with olive skin and sharp features. He wears tailored suits that complement his lean frame and often has a heavy gold chain around his neck. Reynaldo was once a powerful member of the Invictus, serving as a ghoul to one of their most influential leaders. However, a falling out with his master left him stranded and looking for a new purpose in life. Reynaldo's past is shrouded in mystery, but it is known that he hails from a long line of notorious Italian mobsters. He is the last surviving member of the Gui branch of the Piave Crime Family, a fact that he wears like a badge of honor. Reynaldo is a master manipulator and has been able to use his connections in the criminal underworld to carve out a new niche for himself. Despite his murky past, Reynaldo is a charming and charismatic man. He uses his natural charm and silver tongue to win over new allies and convince his enemies to see things his way. He is ruthless when it comes to protecting his interests, but he is also fiercely loyal to those who earn his trust. Reynaldo's strength lies in his ability to read people and situations, and he is always one step ahead of his opponents. As an Independent ghoul, Reynaldo treasures his freedom and autonomy. He is not beholden to any one clan or leader, and he prefers to stay out of Kindred politics as much as possible. However, he is always looking for ways to increase his power and influence, and he is not above forming alliances with other Kindred if it serves his interests.

Oscuro Sangiovanni is a tall, muscular man with a shaved head and a thick beard. He has piercing brown eyes that seem to scrutinize every person he meets. Oscuro is a ghoul underboss for the deadly Giovanni Crime Family, and he takes his job very seriously. He wears expensive tailored suits, but they never quite seem to fit his bulky frame. He has numerous tattoos and scars that hint at a violent past, and he always carries a small silver blade at his side. Oscuro is a skilled fighter, and he is not afraid to get his hands dirty if his job demands it. Oscuro is fiercely loyal to the Giovanni Crime Family and their interests. He is a consummate professional, and he never lets his emotions get in the way of his work. He is also a master strategist, and he regularly comes up with plans to outmaneuver their enemies. Despite his loyalty to his masters, there are whispers that Oscuro harbors secret ambitions of his own. He is not content to stay in his current position forever, and he is constantly looking for ways to increase his own power and influence. He is a shrewd negotiator and has been responsible for many deals that have greatly benefited the Giovanni Crime Family. Oscuro is not known for his friendliness or his sense of humor. He is a cold, calculating man who takes pleasure in inflicting pain on those who cross him or his masters. His reputation as a ruthless enforcer has earned him the respect of underworld figures across the city, and many fear crossing him.

Capo Mario "The Prince" Maneti is a handsome man with chiseled features and jet black hair that he wears slicked back. He wears expensive tailored suits and always has a silver cigarette case on hand. Mario is the leader of the Mariani Crime Family, a powerful smuggling operation that operates under the umbrella of the Piave Family. As a ghoul, Mario is fiercely loyal to his masters in the Daeva clan. He is a true believer in their philosophy of beauty and sensual pleasure, and he embodies those ideals in his persona and in his work. Mario is a smooth talker and a master of seduction, using his charisma and style to win over new allies and enemies alike. Despite his reputation as a "Prince," Mario is not averse to getting his hands dirty when the situation calls for it. He is a skilled fighter and has been known to use his supernatural abilities to get the upper hand in a dangerous situation. However, he prefers to use his wit and charm to avoid violence whenever possible. Mario is a consummate professional, and he takes his role as leader of the Mariani Crime Family very seriously. He is responsible for the day-to-day operations of their smuggling activities, making tactical decisions and negotiating deals with other players in the criminal underworld. He is a shrewd businessman and has made the Mariani Crime Family one of the most successful smuggling operations in the city. Despite his loyalty to the Daeva and the Piave Family, there are whispers that Mario has his own ambitions. He is not content to stay in his current position forever, and he is constantly looking for ways to increase his own power and influence. He is a charismatic leader, and many of his followers are fiercely loyal to him, whether out of respect or fear.

Anastasio "Stoss the Sword" Rocca is a formidable man with a chiseled jaw and a scar that runs from his cheek to his jawline. He wears simple clothing that can accommodate his fluid and graceful movements. Anastasio is a hitman who specializes in using a sword, and he is renowned for his uncanny speed and precision. As a ghoul specializing in celerity, Anastasio is able to move faster than the eye can follow. He is a master of the discipline and has honed his skills to the point where he can move in a blur of motion. He is adept at both offense and defense, and he can anticipate his opponent's moves with frightening accuracy. Anastasio is not a man of many words. He is stoic and measured in his actions, and he only speaks when necessary. He is a consummate professional and is highly sought after in the criminal underworld for his abilities. Despite his reputation as a ruthless killer, Anastasio does have a code of honor. He only takes contracts on those who he deems worthy of death, such as other criminals or corrupt officials. He is also fiercely loyal to those who have earned his trust, and he will go to great lengths to protect them. Anastasio's abilities as a ghoul make him an even more effective killer, as he can move faster than humanly possible and can heal quickly from any injuries sustained in combat. He is a valuable asset to any criminal organization that is lucky enough to have him on their payroll. Despite his cold exterior, there are whispers that Anastasio harbors a deep sadness within him. Some speculate that he became a ghoul as a way to escape the pain of his past, though what that past entails remains a mystery.

Indeed, the Lancea Sanctum typically frowns upon the use of ghouls as they see it as a violation of their beliefs and the sacred bond between the living and the dead. However, in rare instances, there have been instances of Lancea Sanctum members using ghouls to achieve their goals. One such family is the de la Cruz family. Hailing from a traditional Catholic background and with strong ties to the church, the de la Cruz family holds devout beliefs in the Lancea Sanctum's teachings. However, they have also adopted an unorthodox approach to holy work through their use of ghouls. The de la Cruz family has a long history of employing ghouls, seeing them as a necessary evil to carry out the Lancea Sanctum's work. They only employ ghouls who have already committed sins and use them to perform acts of penance by carrying out the family's work. These ghouls are often used as enforcers and soldiers, with the family providing them with a sense of purpose and the opportunity to atone for their past sins. The de la Cruz family is typically tight-lipped about their use of ghouls, knowing that their practices are controversial within the Lancea Sanctum. However, they maintain that their actions are necessary to achieve the greater good and uphold the church's values. Despite their unorthodox practices, the de la Cruz family is deeply respected within the Lancea Sanctum and their work is often sought after by other members of the clan. The family's strong ties to the church also provide them with additional protection and resources, making them a force to be reckoned with in the criminal underworld.